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石振华
发布时间:2017-04-18
石振华
博(硕)士,教授,生物化学与分子生物学硕士研究生导师。生物化学教研室主任。
联系电话:0311-80787579
电子邮件:shizhhtom@126.com
所属专业:生物化学与分子生物学
学习经历:
2005-2008年,中国科学院生物物理研究所/bat365在线登录入口,读博士学位
2001-2003年,bat365在线登录入口,动物学,硕士
1984-1988年,河南师范大学bat365在线登录入口,生物学,学士
主要教学科研工作:
教学方面,主讲本科生《生物化学》、《酶工程》、《生物化学实验》、《酶工程实验》等。生物化学教研室主任,bat365在线登录入口教学委员会委员。
科研方面,从事动物生理生化研究,具体方向有:(1)铁代谢紊乱与神经退行性相关疾病发病机制的研究。(2)铁代谢紊乱与神经肿瘤发病机制的相关性研究:(3)麻醉剂致Alzheimer’s Disease发病的致病机制研究。(4)天然抗氧化剂的神经保护作用机制研究。主要以细胞核动物模型为材料建立模型,生物化学,分子生物学,生理学等方法和技术研究神经退行性疾病的发病机制及其预防措施。现为中国生物化学与生物物理学会会员,Neural regeneration research 杂志审稿人
承担的科研项目:
主持的项目
1. 国家自然基金:线粒体铁蛋白抑制神经肿瘤细胞生长作用机制的研究,81072064,2011-2012,负责人
2. 国家自然基金:线粒体铁蛋白在帕金森氏病中保护机制及其功能的研究,31271146,2013-2016负责人
3. 河北省科技厅,河北省科重点基础研究项目:线粒体铁蛋白在Alzheimer’s disease 中保护机制的研究,10966120D,负责人
近年发表的论文:
1. Zhen-Hua Shi , Fang-Fang Shi ,Yue-Qi Wang , Alex D. Sheftel ,Guangjun Nie , Ya-Shuo Zhao ,Lin-Hao You , Yu-Jing Gou , Xiang-Lin Duan ,Bao-Lu Zhao , Hong-Meng Xu, Chun-Yan Li,
Yan-Zhong Chang. Mitochondrialferritin, a new target for inhibiting neuronal tumor cell proliferation. (SCI ,IF:5.8) ( 2014 )Cellular and Molecular Life Sciences, DOI10.1007/s00018-014-1730-0,
2. Zhenhua Shi, Zhongbing Lu, Yashuo Zhao ,Yueqi Wang, Xi Zhao-Wilson ,Peng Guan ,Xianglin Duan , Yan-Zhong Chang , Baolu Zhao. Neuroprotective effects of aqueous extracts of Uncariatomentosa: Insights from 6-OHDA induced cell damage and transgenicCaenorhabditis elegans model. Neurochemistry International 62 (2013) 940–947 (SCI,IF:2.8)
3.Wen-Shuang Wu, Ya-Shuo Zhao, Zhenhua Shi, Shi-Yang Chang, Guangjun Nie,Xiang-Lin Duan, Song-Min Zhao, Qiong Wu, Zhen-Ling Yang, Baolu Zhao, Yan-ZhongChang*. Mitochondrial ferritin attenuates β-amyloid-induced neurotoxicity: Reduction in oxidative damage throughthe Erk/P38 MAPK pathways. Antioxidants & Redox Signaling. 2013,18(2):158-69. SCI, IF: 8.456
4.Shi, Zhen-Hua, Nie, Guangjun, Duan, Xiang-Lin, Rouault, Tracey, Wu,Wen-Shuang, Ning, Bo, Zhang, Nan, Chang, Yan-Zhong, Zhao,Bao-Lu.Neuroprotective Mechanism of Mitochondrial Ferritin on6-Hydroxydopamine-Induced Dopaminergic Cell Damage: Implication forNeuroprotection in Parkinson's Disease Antioxidants & Redox Signaling, 13(6), pp 783-796, 2010/9(SCIIF:8.2).
5. Shi Zhen-Hua, Xi, Zhao-Wilson, Wang Hao, Guan Peng, Yu Peng, ChangYan-Zhong, Duan Xiang-Lin, Zhao Bao-Lu.The Neuroprotective Effect of Batch-2,an Aqueous Extract From Cat's Claw (Uncaria tomentosa) on 6-OHDA-InducedSH-SY5Y Cell Damage. Progress inBiochemistry and Biophysics, 37(7), pp 769-778, 2010/7(SCIE).
6.Zhao Song-Min, Shi Zhen-Hua, Duan Xiang-Lin, Chang Yan-Zhong.24p3-24p3receptor system: A new pathway of iron transport, Progress in Biochemistry and Biophysics,34(6), pp 557-561, 2007(SCIE).
7. Yuan, Xiang-li, Guo, Ji-feng, Shi, Zhen-hua, Xiao, Zhi-qian, Yan,Xin-xiang, Zhao, Bao-lu, Tang, Bei-sha.R492X mutation in PTEN-induced putativekinase 1 induced cellular mitochondrial dysfunction and oxidative stress, Brain Research, 1351, pp 229-237, 2010/9/10(SCI).
8. Kong, Weina, Duan, Xianglin, Shi, Zhenhua, Chang, Yanzhong.Ironmetabolism in the mononuclear phagocyte system, Progress in Natural Science, 18(10), pp 1197-1202, 2008/10/10
9.Cui, Yanhong, Lu, Zhongbing, Bai, Lin, Shi, Zhenhua, Zhao, Wen-En,Zhao, Baolu.
beta-Carotene induces apoptosis and up-regulates peroxisomeproliferator-activated receptor gamma expression and reactive oxygen speciesproduction in MCF-7 cancer cells.
European Journal of Cancer, 43(17), pp 2590-2601, 2007/11(SCI).
10. Wang N, Guan P, Zhang JP, Li YQ, Chang YZ, Shi ZH, Wang FY, ChuLFasudil hydrochloride hydrate, a rho-kinase inhibitor, suppressesisoproterenol-induced heart failure in rats via JNK and ERK1/2 pathways,Journal of Cellular Biochemistry, 112, pp 1920-1929, 2011.
11. Di X, Yan J, Zhao Y, Zhang J, Shi Z, Chang Y, Zhao B.l-theanineprotects the app (swedish mutation) transgenic sh-sy5y cell againstglutamate-inducedexcitotoxicity via inhibition of the nmda receptor pathway,Neuroscience, 168, pp 778-786, 2010.
12. Zhang Nan, Sheng Qing-hai, Shi Zhen-hua, Zhang Zhi-guo, DuanXiang-lin, Chang Yan-zhong.Application of Solid Sampling Graphite FurnaceAtomic Absorption Spectrophotometry to Mensuration of Brain Iron Content inRats. Spectroscopy and Spectral Analysis, 29(4), pp 1127-1130, 2009/4(SCIE).
专著、教材:
石振华参编,《生命科学导论》,科学出版社,2011年
王冬梅,吕淑霞,石振华. 生物化学,科学出版社,2010
石振华参编,普通高中课程标准实验教科书-生物技术实践,北京师范大学出版社,2009
石振华参编,生物化学习题集,科学出版社,2008
石振华参编,新编高中生物奥赛使用题典,南京师范大学出版社,2008
获奖
1获河北省科技进步三等奖1项。
2 2010年获河北省神经科学学会优秀论文奖1项。
3 2009年获美国Journal of biochemistry优秀青年研究者奖1项。